Gain reproducible insight into particle and molecular behaviour in vaccine systems. Detect instability, optimise formulations and accelerate vaccine development with Zetasizer.
Vaccines rely on complex biological systems where particle size, molecular stability and formulation behaviour directly influence safety, efficacy and manufacturability. From protein subunit vaccines to viral vectors and nanoparticle delivery systems, developers must carefully characterise biological particles to ensure consistent immune response and long-term stability.
However, small changes in particle size, aggregation or molecular interactions can significantly impact vaccine performance. These changes often begin at the nanoscale, long before they can be detected using conventional analytical techniques.
To move forward with confidence, scientists need analytical tools that provide clear, reproducible insight into particle behaviour in solution.
That is why vaccine researchers worldwide rely on Zetasizer, delivering particle and molecular characterisation data they can trust at every stage of development.
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Even well-designed vaccine candidates can face failure in later stages of development due to:
These risks are particularly challenging because they often originate at the nanoscale, long before visible changes occur or traditional techniques can detect them.
Subtle changes in particle size, surface charge and molecular interactions can have a profound impact on vaccine stability, efficacy and manufacturability. These early instabilities are often missed during initial screening and only become apparent under real-world conditions such as scale-up, storage or distribution.
Zetasizer is designed to uncover these hidden risks earlier in development.
Using highly sensitive dynamic light scattering (DLS) and zeta potential analysis, Zetasizer detects even the smallest changes in particle size and surface charge.
This enables scientists to identify early-stage instability, aggregation and interaction changes before they become critical issues. The result is faster, more informed decision-making and reduced risk of late-stage failure.
Particle instability is one of the leading causes of reduced vaccine efficacy. Aggregation, particle growth or structural changes can compromise antigen performance and consistency.
The challenge is that these instabilities often begin at the nanoscale, making them difficult to detect using traditional methods. Zetasizer reveals these early changes with exceptional sensitivity.
By measuring subtle shifts in particle size distribution using dynamic light scattering, Zetasizer enables researchers to monitor vaccine stability directly in solution throughout development.
With Zetasizer, vaccine researchers can:
✔ Detect early particle aggregation before visible instability occurs
✔ Monitor nanoparticle, antigen or viral vector size during development
✔ Compare vaccine candidates with greater analytical confidence
The result is earlier identification of stability risks and more robust vaccine design.
Vaccines must remain stable across manufacturing, storage, distribution and administration. Even minor changes in pH, buffer composition or excipient interactions can significantly affect particle behaviour and antigen stability.
Zetasizer provides powerful insight into formulation stability.
By measuring both particle size and zeta potential, Zetasizer helps scientists understand how vaccine components interact in solution and predict whether systems will remain stable or begin to aggregate.
This enables rapid screening of formulation conditions and identification of those that support long-term stability.
With Zetasizer, scientists can:
✔ Evaluate particle stability across multiple formulation conditions
✔ Predict colloidal stability using surface charge measurements
✔ Identify buffer systems that minimise aggregation risk
This insight allows teams to design more stable vaccine formulations earlier in development.
Modern vaccines increasingly rely on advanced delivery platforms such as nanoparticles, viral vectors, protein subunits and adjuvant systems. While these enhance immune response, they also introduce additional complexity in particle behaviour.
Understanding how these systems behave in solution is essential for ensuring consistent performance and manufacturability. Zetasizer provides detailed insight at the particle level.
Dynamic light scattering enables precise measurement of size distribution and interaction behaviour, helping researchers evaluate how delivery systems respond to formulation and processing conditions.
With Zetasizer, vaccine developers can:
✔ Characterise particle size and distribution with high sensitivity
✔ Monitor nanoparticle and viral vector behaviour during development
✔ Ensure consistent particle properties across formulations
This deeper understanding supports confident development of complex vaccine systems.
Automated workflows powered by the Sample Assistant bring greater consistency and control to vaccine analysis. By standardising sample loading, measurement and data analysis, the system reduces operator variability and ensures that every sample is handled in the same way. This is critical when working with sensitive biological particles, where small inconsistencies can mask early signs of instability.
For vaccine systems involving nanoparticles, proteins or viral vectors, detecting subtle changes requires both sensitivity and reproducibility. The Sample Assistant delivers consistent measurement conditions across every run, enabling reliable comparison of vaccine candidates and formulation strategies.
Designed for high-throughput environments, the system allows efficient screening of multiple samples without compromising analytical performance. Dynamic light scattering and zeta potential measurements retain full sensitivity, while automation ensures reproducible datasets across larger studies.
By embedding consistency into every stage of analysis, automated workflows help vaccine development teams generate high-quality data they can trust. The result is clearer insight, improved efficiency and greater confidence in advancing vaccine candidates.
Zetasizer combines analytical sensitivity, reproducibility and ease of use to address the complex challenges of vaccine development. From early research through formulation and stability testing, it provides the insight needed to understand particle behaviour in solution and reduce development risk.
With Zetasizer, you can:
✔ Detect early-stage particle aggregation with high-sensitivity dynamic light scattering (DLS)
✔ Measure zeta potential to understand surface charge and predict formulation stability
✔ Characterise nanoparticle, antigen and viral vector behaviour in solution
✔ Compare formulation conditions including pH, buffers and excipients with confidence
✔ Monitor particle behaviour at high concentrations and across processing conditions
✔ Generate highly reproducible data to support confident decision-making
✔ Enable high-throughput, standardised workflows with the Sample Assistant
✔ Screen vaccine candidates efficiently to identify stable formulations
✔ Reduce the risk of late-stage instability and reformulation
✔ Accelerate vaccine development timelines
By delivering reliable, reproducible insight into particle and molecular behaviour, Zetasizer enables scientists to make better decisions earlier, supporting the development of safe, stable and effective vaccines with confidence.
Measure protein size and detect aggregation to optimise stability and support biologic drug development.
Characterise nanoparticle size and surface charge to optimise delivery efficiency and stability.
Verify particle size and stability to maintain product quality and regulatory compliance.
Analyse vesicle size and aggregation to support emerging therapeutic applications.
Characterize protein stability, aggregation and molecular behaviour to ensure efficacy and shelf life.
Analyse particle size and stability of antigens and delivery systems for effective vaccine performance.
Measure viral vector size and stability to ensure safe and effective gene delivery.
Understand nanoparticle size and surface properties to control drug release and targeting.
Measure size, zeta potential and concentration using DLS and NTA. Detect instability early and optimise biologics with Zetasizer and NanoSight.
The basics of Dynamic Light Scattering and electrophoretic light scattering will be discussed. I will review the Dynamic Light Scattering acronyms, i.e what is meant by NIBS and MADLS.
ZetaClass is a comprehensive webinar series on dynamic and electrophoretic light scattering where our experts walk you through the basic measuring principles, data interpretation, and tests performed to gauge data quality.
Join us as we unveil the new and expanded Zetasizer range: Zetasizer Advance. Dr Mike Kaszuba will introduce the new range and help you to pinpoint which system best fits your particle characterization requirements.
This webinar discusses some basic fundamentals of light scattering science and also common misconceptions about light scattering methods
In this webinar, you will learn about developing reliable and effective methods for dynamic light scattering (DLS) and electrophoretic light scattering (ELS) measurements using the Zetasizer Advance instrument. The presentation is geared toward users of DLS and ELS instruments who want to deepen their understanding of method development.
This webinar will explore how the Dynamic Light Scattering (DLS) technique, utilized by the Zetasizer Advance series, ensures compliance with United States Pharmacopeia (USP) guidelines, specifically USP 430.
This webinar will discuss each of the sections contained in United States Pharmacopeia (USP) 432 and what it means for users of Malvern Panalytical’s Zetasizer range of instruments who measure zeta potential in their workflow.
Join us to learn how to assess the quality of your data collected on the Zetasizer Advance instrument. Together we will go through real examples of data from particle size measurements that use Dynamic Light Scattering (DLS) and zeta potential measurements obtained with Electrophoretic Light Scattering (ELS) assessing data quality and sharing tips on how to improve confidence in the results.