
Zetasizer Masterclass 1:
DLS Method Development
This is the first masterclass of a four-part Masterclass series where we will discuss method development for dynamic light scattering sizing measurements with the Zetasizer Advance series.
Light scattering for every application
Pinoneering systems for nanoparticle, colloid and biomolecular particle sizing and particle charge measurements
Step into the world of precise particle sizing with our Zetasizer family! From sub-nanometer wonders to micrometer marvels, we've got you covered. Explore Dynamic Light Scattering for size, Electrophoretic Light Scattering for mobility and charge, and Static Light Scattering for molecular weight analysis. Elevate your lab with the Zetasizer Advance – the next-gen successor to our beloved Nano range!
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This is the first masterclass of a four-part Masterclass series where we will discuss method development for dynamic light scattering sizing measurements with the Zetasizer Advance series.
In the second part of this masterclass series we will highlight various factors that need to be considered when creating robust measurement procedures, from instrument verification, cell selection, sample preparation, measurement set up and result analysis.
In the third part of the masterclass series we will highlight the key parameters and charts available in ZS Xplorer software to help with data interpretation, and how to configure the software to display them.
In this masterclass we will highlight the key parameters and charts available in ZS Xplorer software to help with interpretation, how to configure the software to display them, be able to recognise good and poor data, understand the reasons why data is poor and what can be done to improve it.
In this webinar, you will learn about developing reliable and effective methods for dynamic light scattering (DLS) and electrophoretic light scattering (ELS) measurements using the Zetasizer Advance instrument. The presentation is geared toward users of DLS and ELS instruments who want to deepen their understanding of method development.
This webinar will explore how the Dynamic Light Scattering (DLS) technique, utilized by the Zetasizer Advance series, ensures compliance with United States Pharmacopeia (USP) guidelines, specifically USP 430.
This webinar will discuss each of the sections contained in United States Pharmacopeia (USP) 432 and what it means for users of Malvern Panalytical’s Zetasizer range of instruments who measure zeta potential in their workflow.
Join us to learn how to assess the quality of your data collected on the Zetasizer Advance instrument. Together we will go through real examples of data from particle size measurements that use Dynamic Light Scattering (DLS) and zeta potential measurements obtained with Electrophoretic Light Scattering (ELS) assessing data quality and sharing tips on how to improve confidence in the results.
The first masterclass in the series aims to provide an introduction to dynamic light scattering for particle sizing. Starting from the very basics, the webinar is designed to introduce newcomers to the technique as well as serving as a reminder for more experienced users.
Join our masterclass to explore the fundamentals of Electrophoretic Light Scattering (ELS) and zeta potential. Learn the basics of electrokinetic theory, particle charge, and how our Zetasizer Advance Range instruments use light scattering to measure zeta potential. Enhance your expertise in this short, engaging session
In this masterclass we will highlight the key parameters and charts available in ZS Xplorer software to help with data interpretation, and how to configure the software to display them. Furthermore, we will discuss how we can recognise good and poor data, understand the reasons why the data could be poor and what steps can we can take to improve it.
In this masterclass we will highlight the key parameters and charts available in ZS Xplorer software to help with interpretation, how to configure the software to display them, be able to recognise good and poor data, understand the reasons why data is poor and what can be done to improve it.
In this masterclass we will highlight various factors that need to be considered when creating a robust sizing measurement, from instrument verification, cell selection, sample preparation, measurement set up and result analysis.
In this masterclass we will connect students, researchers, and professors with expert speakers who will answer questions and share practical advice that can help take your research to the next level.
The Zetasizer advance series includes 3 blue label and 3 red label versions of the Lab, Pro, and Ultra models. Which best suits your needs? Discover their shared features, shared features for Pro and Ultra models, and shared features for Ultra models.
Discover the most common myths and assumptions about light scattering, and how much truth there is to them: do molecular weight measurements with SLS require multiple angles? Is DLS suitable for samples that contain aggregated or agglomerated materials? Do ELS or Zeta potential measurements “cook” biological samples? Does accurate DLS analysis require precise instrument calibration? Find out the answers to these questions and more!
Get off to a great start with your Zetasizer instrument. After a brief summary of the device features, follow two live demonstrations: one with an aggregated sample and one with a dual-measurement method setup. Learn how to check data quality and discover the configurability of the Zetasizer, including the ability to change input settings post-measurement.
DLS is one of the flagship technologies of the Zetasizer Advance series. What does a DLS instrument consist of? How do you interpret and analyze the correlation function? Find the answers to the questions through detailed explanations and application examples of the different Zetasizer distribution measurements.
What is adaptive correlation? Discover the issues faced by traditional DLS users, the solutions adaptive correlation provides, and how these result in better data with less preparation. Following this, learn how even unusual data can be measured and how to measure low-scattering samples, concluding with customer success stories.
Learn why MADLS is used for particle concentration measurements and see its strengths compared to single angle measurements. Explore the parameters that can affect your measurements. Then, discover how intelligent data quality guidance helps you resolve potential issues and have full confidence in your results.
After a summary of MADLS and best practices, take a deep dive into what can affect particle and concentration measurements through three practical examples: concentration measurements of 30 nm gold particles, Liposome size and concentration measurements and AAV Capsid titer by MADLS-based assay.
After a summary of DLS and ELS, discover key insights for measurements with your Zetasizer instrument. These include how to use the correlogram and phase plot to boost confidence in your results, the importance of diluting samples for ELS, as well as checking whether the concentration is suitable and choosing your measuring cells accordingly. You’ll also learn how to use DLS to measure sample viscosity. Following the bonus tips on using our knowledge center and our e-store for consumables, the audience questions is also of great value, featuring the questions of Zetasizer users from a variety of fields.
What does a good-quality correlogram look like? What does it represent? Go through the different tests that assess data quality, including cumulants and distribution fit tests, count rate repeatability, z-average diameter repeatability, repeatability of size distributions and many more. The webinar then includes a similar walkthrough of how the phase plot is used to check zeta potential data quality.
After an in-depth breakdown of the theory of DLS, discover the algorithms behind any dynamic light scattering analysis. With these in hand, discover data interpretation tips that continue to be relevant, the types of noise that can affect your results and their solutions and the customer training we continue to provide.
Explore what correlation means in DLS, how the correlation function is modeled, how to interpret & analyze it, and the role of NIBS in cumulants analysis. These explanations feature a more in-depth look at some of the math behind the Zetasizer features and what to do and look out for to ensure good-quality MADLS data.
Which parameters should you report when presenting DLS data? Learn how cumulants analysis works for monomodal and multimodal samples, how cumulants and distribution analysis compare, and which size distributions you should present in various contexts. Discover the parameters we recommend you use when presenting DLS results, how to add these parameters to your software, and follow three practical demonstrations.
How does our technical support assist you? Explore the resources we put at your disposal in our knowledge centre and then discover how we would answer your questions through a variety of examples. These include how we’d help you navigate sample dilation, interpret more than one peak in a zeta potential run, dilute samples without compromising data accuracy, and find the best analysis strategy for protein nanoparticle zeta potential measurements.
There are many acronyms that describe light scattering technology – learn what these are and what’s behind them, the key points to look at in Zetasizer measurements, how to determine the quality of your data, applications for Zetasizer particle size measurements and Zeta potential measurements.
In what industries is Zetasizer most commonly used? Explore the applications of nanoparticle, why Zetasizer features are so important to their analysis, and the best-suited applications for each Zetasizer model. Take an in-depth dive into the Zetasizer series’ applications in the industries of energy storage and generation, catalysts, paints, coatings and inks and pharmaceuticals.
Get a synposis of the key parameters and charts available in ZS Xplorer software to help with data interpretation. You also get access to important resources on how to recognize good and poor data, understand the reasons why the data could be poor, and what steps you can take to improve it.
The webinar discussed the development of robust and reliable methods for successful and repeatable zeta potential measurements using a Zetasizer Advance instrument. Specifically, it covered the following:
Get a synopsis of method development for dynamic light scattering sizing measurements with the Zetasizer Advance series. We highlight various factors that need to be considered when creating a robust sizing measurement, from instrument verification, cell selection, sample preparation, measurement set up and result analysis. Bonus, you receive some easy access link too!
Become familiar with how to configure key parameters in the tables and select key charts that are available in ZS Xplorer software. Understand what each key parameter and chart available means and the information they provide to the user to aid with interpretation. Understand the possible benefits of averaging records to improve repeatability of results
This handout accompanies the webinar ‘Mastering Light Scattering Techniques Masterclass 1: Basics of Dynamic Light Scattering’