Protein stability and shelf life
Trust every result, every time.
The Zetasizer: For scientists developing next-generation biologics and pharmaceutical innovations.
The Zetasizer: For scientists developing next-generation biologics and pharmaceutical innovations.
Malvern Panalytical's Zetasizer Advance Range delivers high-sensitivity Dynamic Light Scattering (DLS) and zeta potential analysis to support biologics development, vaccine research and advanced drug delivery systems - providing reproducible data scientists can trust at every stage of their process.
Each of the three models in the Zetasizer Advance Range (Lab, Pro and Ultra) offers particle size, particle charge (zeta potential) and molecular weight analysis. In addition, each benefits from advances including Adaptive Correlation, M3-PALS zeta potential analysis, constant current zeta mode and our deep learning-based data quality advice system. These help you understand critical attributes - including aggregation behaviour, formulation performance and degradation pathways - all of which are vital to ensuring drug stability, efficacy and regulatory compliance.
Measuring particle size in pharmaceutical and biologics formulations isn’t straightforward. Complex samples, low concentrations and sensitivity to environmental conditions can all affect data quality.
Even small inconsistencies in sample preparation or instrument settings can lead to variable results - making it harder to accurately detect aggregation, assess stability or compare formulations.
The result? Slower development, uncertain decisions and increased risk at critical stages of the pipeline.
With Zetasizer you can:
✔ Measure protein and nanoparticle size with exceptional sensitivity
✔ Predict formulation stability using zeta potential
✔ Detect aggregation early in biologics development
✔ Generate highly reproducible, regulatory-ready data
In biologics and pharmaceutical development, even minor changes in particle size, aggregation or surface charge can have major consequences for:
Without reliable analytical data, teams risk delayed development, failed formulations and challenges during scale-up and approval.
Through reproducibility of robust data insights, Zetasizer enables confident characterisation of proteins, nanoparticles and complex pharmaceutical systems, helping you reduce risk and move forward with certainty.
Understanding surface charge is essential for predicting formulation stability - but measuring zeta potential in real-world pharmaceutical conditions can be challenging.
High-salt buffers and biologically relevant environments often reduce measurement sensitivity, while poor reproducibility can make it difficult to draw reliable conclusions.
For scientists working in regulated environments, this variability can create barriers to confident decision-making, comparability studies and regulatory approval.
Zetasizer is designed to overcome the key challenges of zeta potential measurement, giving you confidence in even the most complex pharmaceutical environments:
Measure protein size and detect aggregation to optimise stability and support biologic drug development.
Characterise nanoparticle size and surface charge to optimise delivery efficiency and stability.
Verify particle size and stability to maintain product quality and regulatory compliance.
Analyse vesicle size and aggregation to support emerging therapeutic applications.
Characterize protein stability, aggregation and molecular behaviour to ensure efficacy and shelf life.
Analyse particle size and stability of antigens and delivery systems for effective vaccine performance.
Measure viral vector size and stability to ensure safe and effective gene delivery.
Understand nanoparticle size and surface properties to control drug release and targeting.
Measure size, zeta potential and concentration using DLS and NTA. Detect instability early and optimise biologics with Zetasizer and NanoSight.
The Malvern Panalytical Zetasizer is the industry benchmark for particle size analysis, DLS and zeta potential measurement - giving you complete confidence in your data from early discovery through to manufacturing and quality control.
Across pharmaceutical innovation, nanoparticle research, drug manufacturing and quality control and assurance, scientists rely on Zetasizer to deliver accurate, reproducible and trusted data; because when your samples define performance, you need results you can rely on.
Excellent system for characterizing nanoparticles in terms of their Physicochemical properties (size, concentration, polydispersity, and zeta potential). I like the system because it consumes only a few microliters of precious samples to determine and analyze all the properties mentioned above. I highly recommend this system for particle analysis."
Ashwini Mishra — AAVinue Inc.
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