Gain reproducible insight into particle and molecular behaviour in vaccine systems. Detect instability, optimise formulations and accelerate vaccine development with Zetasizer.
Modern therapeutics increasingly rely on advanced vaccine platforms and engineered drug delivery systems. From viral vectors and recombinant proteins to lipid nanoparticles and polymer-based carriers, these technologies are transforming how treatments are designed, delivered, and scaled. Their success depends on precise control of particle characteristics that directly influence efficacy, safety, and reproducibility.
Across both vaccines and delivery systems, performance is governed at the nanoscale. Particle size, concentration, and structural integrity determine how therapies behave in biological environments, from biodistribution and cellular uptake to immune response and release kinetics. Even small variations in particle populations can lead to meaningful differences in clinical outcomes.
These systems are inherently complex. Multi-component formulations often contain heterogeneous and dynamic particle populations that evolve in response to formulation conditions, manufacturing processes, and storage environments. Maintaining consistency across development stages is therefore a significant scientific and analytical challenge. That’s where Malvern Panalytical's NanoSight Pro gives you the reproducible, reliable data to make those early-stage decisions that make the difference in vaccine development.
With NanoSight Pro you can:
✔ Detect subtle changes in particle populations before they impact performance
✔ Gain particle-level insight into complex, heterogeneous systems
✔ Generate reproducible data to support development and regulatory confidence
Works with OmniTrust: Malvern Panalytical's compliance solution for the regulated environment
Advanced vaccine and drug delivery systems carry hidden risks that often emerge too late in development. These risks originate from subtle nanoscale changes that are difficult to detect but can significantly impact stability, efficacy, and manufacturability. Without the right analytical approach, these issues remain invisible until they affect product performance.
These risks are challenging to detect because they originate at the level of individual particles. Conventional techniques often provide averaged data, which can mask early-stage instability or low-level sub-populations. As a result, critical changes remain hidden until they manifest as late-stage failures or inconsistencies.
Many vaccine and drug delivery programmes progress successfully through early development, only to encounter issues during scale-up, storage, or real-world application. This is often due to subtle nanoscale changes that accumulate over time, altering particle behaviour in ways that are not initially visible.
Small shifts in particle populations can influence stability, delivery efficiency, and biological performance. These effects may only become apparent under stress conditions, extended storage, or manufacturing variability, leading to delays, reformulation, or regulatory challenges.
NanoSight Pro addresses this challenge through nanoparticle tracking analysis, enabling direct visualisation and measurement of individual particles in solution. This approach provides early detection of changes in particle size, concentration, and distribution, supporting more informed decision-making throughout development.
Stability is critical for both vaccine efficacy and drug delivery performance. Early-stage aggregation or subtle shifts in particle populations can compromise product quality long before they are detected by conventional methods.
NanoSight Pro enables direct observation of particles in suspension, allowing researchers to identify emerging instability at an early stage. By resolving individual particle movements and distributions, it provides a clear view of how formulations evolve over time and under different conditions.
With NanoSight Pro, you can:
Gain the clarity to act early, refine with confidence, and make informed decisions at every stage - so your formulations remain stable, effective, and ready to perform when it matters most.
Formulation design plays a critical role in determining how vaccines and delivery systems perform in vivo. Achieving the right balance of particle size, concentration, and stability is essential for consistent therapeutic outcomes.
NanoSight Pro provides detailed insight into how formulation variables influence particle populations.
This enables researchers to refine compositions, processing conditions, and delivery strategies with greater precision and confidence.
With NanoSight Pro, you can:
Turn deeper insight into smarter formulation decisions, so you can optimise performance, enhance consistency and confidently progress therapies from development to real-world impact.
Vaccine and drug delivery systems are rarely uniform. They often contain multiple particle populations that interact and evolve over time, influencing overall performance. Understanding this heterogeneity is essential for effective development.
NanoSight Pro enables particle-by-particle analysis, revealing the true complexity of these systems. By distinguishing between sub-populations and tracking their behaviour, it provides a deeper understanding of how formulations function in real-world conditions.
With NanoSight Pro, you can:
✔ Resolve heterogeneous particle populations within complex formulations
✔ Track changes in particle behaviour under different conditions
✔ Gain deeper insight into interactions between formulation components
Unlock a clearer understanding of complexity, so you can make better-informed decisions, refine your approach with precision and develop more effective, reliable delivery systems.
Automated workflows powered by the Sample Assistant bring greater consistency and control to vaccine analysis. By standardising sample loading, measurement and data analysis, the system reduces operator variability and ensures that every sample is handled in the same way. This is critical when working with sensitive biological particles, where small inconsistencies can mask early signs of instability.
For vaccine systems involving nanoparticles, proteins or viral vectors, detecting subtle changes requires both sensitivity and reproducibility. The Sample Assistant delivers consistent measurement conditions across every run, enabling reliable comparison of vaccine candidates and formulation strategies.
Designed for high-throughput environments, the system allows efficient screening of multiple samples without compromising analytical performance. Dynamic light scattering and zeta potential measurements retain full sensitivity, while automation ensures reproducible datasets across larger studies.
By embedding consistency into every stage of analysis, automated workflows help vaccine development teams generate high-quality data they can trust. The result is clearer insight, improved efficiency and greater confidence in advancing vaccine candidates.
NanoSight Pro delivers the resolution and clarity required to characterise modern vaccine and drug delivery platforms. By combining nanoparticle tracking analysis with precise concentration measurement, it provides a comprehensive understanding of particle systems that are otherwise difficult to analyse.
This level of insight supports more efficient development, reduces risk, and enables greater confidence in both formulation and manufacturing decisions. For teams working with increasingly complex therapeutic platforms, it offers a clear path to improved performance and reproducibility.
✔ Direct particle-by-particle analysis using nanoparticle tracking analysis
✔ High-resolution measurement of particle size and distribution
✔ Accurate nanoparticle concentration measurement by size
✔ Detection of low-level aggregation and emerging sub-populations
✔ Real-time monitoring of formulation and environmental effects
✔ Improved formulation optimisation and process control
✔ Enhanced batch-to-batch consistency
✔ Reduced risk of late-stage development failure
✔ Stronger data to support regulatory submissions
✔ Faster, more confident decision-making across development
NanoSight Pro enables scientists to see what other techniques miss, providing clear, actionable insight at the point where it matters most. By supporting better decisions earlier in development, it reduces risk, accelerates timelines, and ensures greater confidence in vaccine and drug delivery performance from formulation through to real-world application.
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Gain reproducible insight into particle and molecular behaviour in vaccine systems. Detect instability, optimise formulations and accelerate vaccine development with Zetasizer.