Characterise extracellular vesicles in cell therapy. Gain nanoscale insight into cell health, potency, and consistency with NanoSight Pro.
Cell therapies are redefining modern medicine. From CAR-T and TCR therapies to stem cell-based treatments, these advanced modalities rely on living cells to deliver therapeutic effects through dynamic, real-time biological interactions. Unlike traditional pharmaceuticals, their efficacy is not fixed but continuously shaped by how cells behave within complex biological environments.
A critical component of this behaviour lies beyond the cell itself. Therapeutic cells actively release extracellular vesicles and other nanoscale particles that mediate signalling, influence immune responses, and contribute to therapeutic outcomes. These nanoscale components form an essential but often under characterised layer of biological activity.
Understanding this nanoscale environment is essential for ensuring therapeutic performance. Extracellular vesicles can provide direct insight into cell health, potency, and functional state, while also acting as indicators of consistency across manufacturing batches. However, their complexity and variability present significant analytical challenges.
These particle populations are highly heterogeneous and sensitive to culture conditions, processing steps, and storage environments. Subtle changes can lead to measurable shifts in vesicle size and concentration, with direct implications for product quality and efficacy. Capturing these changes requires analytical techniques capable of resolving complex, dynamic systems at the particle level.
With NanoSight you can:
✔ Directly measure extracellular vesicle size and concentration in complex samples
✔ Reveal nanoscale indicators of cell health, potency, and activity
✔ Generate reproducible data to support process control and development decisions
NanoSight Pro sets the benchmark for nanoscale analysis in cell therapy by delivering best-in-class nanoparticle tracking analysis with true particle-level resolution.
NanoSight Pro enables researchers to move beyond traditional cell-based metrics and gain precise insight into the vesicle populations that influence therapeutic performance. In a field defined by biological complexity, NanoSight Pro provides the clarity and confidence needed to fully understand and control cell therapy systems.
Works with OmniTrust: Malvern Panalytical's compliance solution for the regulated environment
Cell therapy development operates at the intersection of biology, engineering, and precision control, where success depends on understanding not only the cells themselves but the complex nanoscale environment they create. While significant emphasis is placed on cell viability, phenotype, and expansion, critical indicators of therapeutic performance often exist beyond these traditional metrics.
Extracellular vesicles and other nanoscale particles act as active mediators of cell signalling and function, yet subtle, undetected changes in these populations can introduce risk at every stage of development. Without the ability to accurately characterise and monitor these particles, developers face blind spots that can compromise consistency, efficacy, and ultimately clinical success.
These risks are inherently difficult to detect because they originate at the nanoscale, where even minor changes in particle size, distribution, or concentration can have meaningful biological consequences.
Conventional analytical techniques often rely on bulk measurements or lack the resolution to resolve heterogeneous populations, making it challenging to identify subtle but significant variations. As a result, critical insights are missed, leaving gaps in understanding that can surface later as variability, reduced efficacy, or failure during scale-up and clinical application.
NanoSight Pro addresses these challenges by enabling direct, particle-by-particle analysis through nanoparticle tracking analysis. By measuring size and concentration while visualising particles in real time, it reveals nanoscale dynamics that are otherwise hidden within complex samples.
NanoSight Pro combines sensitivity, precision, and real-time insight to expose hidden variability early in development. This empowers teams to close critical knowledge gaps, strengthen process control, and ensure more consistent and reliable therapeutic outcomes.
Many cell therapy programmes progress successfully through early development based on cell-level metrics such as viability, phenotype, and expansion. However, these measurements do not fully capture the nanoscale environment that influences therapeutic behaviour.
Subtle changes in extracellular vesicle populations can emerge during scale-up, processing, or storage, where shifts in conditions alter particle release and composition. These changes may not be apparent until late-stage development or clinical application, where they can affect potency, stability, or patient response.
NanoSight Pro addresses this challenge by applying nanoparticle tracking analysis to directly measure and visualise individual particles in suspension. This enables early detection of changes in vesicle populations, providing actionable insight that supports better-informed decisions and reduces the risk of late-stage failure.
With its ability to deliver high-resolution, early-stage insight into particle behaviour, NanoSight Pro sets the standard for proactive risk management in cell therapy development. By identifying critical changes before they impact performance, it enables more efficient development and greater confidence at scale.
Extracellular vesicle populations are highly sensitive indicators of cell state and function. Changes in size distribution or concentration can reflect shifts in cell health, stress responses, or therapeutic activity. Capturing these changes early is essential for maintaining product quality.
NanoSight Pro enables direct visualisation of these nanoscale dynamics, allowing researchers to detect subtle variations that would otherwise remain hidden. This provides a clearer understanding of how process conditions influence therapeutic cells and their outputs.
With NanoSight Pro, you can:
✔ Identify shifts in vesicle size distributions linked to cell state
✔ Detect early signs of instability or process-induced variation
✔ Monitor particle population changes across development stages
NanoSight Pro redefines sensitivity in cell therapy analysis. As a best-in-class platform, it enables early detection of the nanoscale changes that directly influence therapeutic performance, supporting stronger process understanding and more robust product quality.
Consistency is a central challenge in cell therapy manufacturing. Variability in culture conditions, handling, and scale-up can lead to differences in extracellular vesicle production, which in turn affects therapeutic performance.
By providing quantitative particle concentration data by size, NanoSight Pro enables more precise monitoring of batch-to-batch variability. This supports tighter process control and helps ensure reproducibility across manufacturing runs.
With NanoSight Pro, you can:
✔ Quantify vesicle concentration to assess batch consistency
✔ Track the impact of process changes on particle output
✔ Strengthen analytical frameworks for scale-up and production
By delivering precise, reproducible measurement at the particle level, NanoSight Pro sets a new standard for manufacturing control. Its best-in-class capabilities enable greater consistency, improved reproducibility, and more confident scale-up of complex cell therapy products.
Cell-derived nanoparticle populations are inherently heterogeneous, consisting of multiple sub-populations with distinct biological roles. Understanding this complexity is key to unlocking deeper insight into therapeutic mechanisms.
NanoSight Pro analyses individual particles in suspension, enabling the resolution of mixed populations and the identification of distinct sub-groups. This provides a more complete picture of the nanoscale environment surrounding therapeutic cells.
With NanoSight Pro, you can:
✔ Differentiate between heterogeneous vesicle sub-populations
✔ Analyse particle behaviour in biologically relevant conditions
✔ Link nanoscale particle data to therapeutic function and activity
NanoSight Pro enables a level of insight that transforms understanding of living systems. By fully resolving nanoscale complexity, it supports better decision-making, improved product design, and deeper insight into mechanisms of action.
NanoSight Pro provides a critical bridge between traditional cell-based assays and the nanoscale environment that drives therapeutic outcomes. By delivering direct, particle-level insight, it enables a deeper understanding of how living therapies behave, interact, and perform.
This capability strengthens development strategies, enhances process control, and supports more robust product characterisation across the entire cell therapy workflow.
✔ Nanoparticle tracking analysis for direct particle visualisation
✔ Measurement of particle size and concentration in real time
✔ High-resolution analysis of heterogeneous vesicle populations
✔ Detection of subtle changes linked to process conditions
✔ Improved monitoring of cell health and therapeutic activity
✔ Enhanced batch-to-batch consistency and reproducibility
✔ Greater confidence in scale-up and manufacturing decisions
✔ Reduced risk of late-stage development failure
✔ Faster, data-driven optimisation of cell therapy processes
✔ Deeper insight into nanoscale mechanisms of action
NanoSight Pro is the definitive solution for cell therapy analysis. Combining precision, sensitivity, and depth of insight, it sets the industry standard for nanoparticle characterisation in advanced therapies. By turning complex nanoscale data into clear, actionable understanding, it enables organisations to reduce risk, accelerate development, and deliver more consistent, effective cell-based treatments.
With deeper insight at every stage, you can avoid costly delays, strengthen your data and move your biologics forward with greater speed, control and confidence.
Analyse ADC heterogeneity and stability with NanoSight Pro. Detect aggregation early and optimise conjugation with particle-level insight.
Characterise extracellular vesicles in cell therapy. Gain nanoscale insight into cell health, potency, and consistency with NanoSight Pro.
Analyse extracellular vesicles with precision using NanoSight Pro. Detect heterogeneity, quantify particles, and de-risk exosome development. Gain reproducible insight into vesicle behaviour in solution.
Characterise viral vectors with precision using NanoSight Pro. Measure size, concentration, and aggregation to support gene therapy development.
Characterize lipid nanoparticles with precision using NanoSight Pro to optimise delivery, stability, and performance in biopharma development.
Detect protein aggregation early with NanoSight Pro. Gain particle-level insight to improve stability, reduce risk, and accelerate biologics development.
Characterise nanomedicine particles with precision using NanoSight Pro. Improve stability, targeting, and development outcomes.
Discover how NanoSight Pro supports Quality Control and Quality Assurance by delivering reliable, reproducible data for regulatory compliant biologics and pharmaceutical development and manufacturing.
Gain reproducible insight into particle and molecular behaviour in vaccine systems. Detect instability, optimise formulations and accelerate vaccine development with Zetasizer.