Zetasizer Nano support ends in 2027

Get ahead of the curve and upgrade your workflow now before obsolescence slows you down.

Zetasizer Nano Support ends in 2027

Your Zetasizer Nano has delivered trusted results for years - but as laboratory demands evolve, ageing systems can begin to impact workflow efficiency, software compatibility, and operational confidence.

With support for the Zetasizer Nano platform ending in August 2027, now is the time to begin your transition to the latest Zetasizer Advance range.

Built for modern laboratories, the Zetasizer Advance platform helps teams reduce workflow friction, improve data confidence, and accelerate decision-making.

 

Om_logo.png  Works with OmniTrust: Malvern Panalytical's compliance solution for the regulated environment

 

Speak to a specialist now to arrange your upgrade
 

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The risks of waiting too long to upgrade

We are now half way through 2026, and even though your Zetasizer Nano may still be performing reliably today - with official support ending in 2027, delaying upgrade planning can introduce growing budgetary, operational and workflow risks that become increasingly difficult to manage over time.

For many laboratories, the challenge is not a sudden instrument failure. The greater risk is reaching a point where support, software compatibility, spare components, and critical accessories become harder to access - often at the exact moment the instrument is most relied upon.

Planning ahead and talking to our experts now now will help you mitigate these risks and avoid reactive decisions later.

Best effort technical support after 2027

Once official support for the Zetasizer Nano range ends in October 2027, laboratories will no longer be able to put their Zetasizer under service contracts, repair will be best efforts and spare part availability cannot be guaranteed.  We will make every effort to support your system, but what we can do will be more and more limited as spares etc. run out, causing possibly significant operational challenges for your lab, including:

  • Longer resolution times for instrument issues
  • Reduced access to specialist technical expertise
  • Increased pressure on internal teams to troubleshoot problems
  • Greater risk of prolonged downtime
  • More uncertainty around maintaining measurement continuity

For laboratories operating under tight project timelines, regulated environments, or high-throughput workflows, losing direct platform support can quickly become a business continuity concern.

No future software updates or compatibility improvements

Laboratory software environments continue to evolve rapidly, with ongoing changes to operating systems, cybersecurity standards, IT policies, and digital infrastructure requirements.

After support ends, Zetasizer Nano users will no longer receive:

  • Software upgrades
  • Compatibility updates for newer operating systems
  • Security-related improvements
  • Enhancements for data handling or workflow functionality
  • Ongoing support for evolving IT environments

As laboratories modernize their digital ecosystems, older unsupported software will become increasingly difficult to maintain within secure and compliant environments.

Over time, this will create additional burdens for both laboratory and IT teams - particularly when integrating legacy systems into modern workflows.

Obsolescence of accessories and add-ons

With 2027 on the horizon, the availability of accessories, replacement components, and add-ons can become increasingly limited.

Laboratories that rely heavily on specific workflows, measurement configurations, or application setups may face growing challenges sourcing compatible parts and maintaining operational flexibility.

This will impact:

  • Measurement continuity
  • Workflow scalability
  • Method consistency
  • Instrument uptime
  • Long-term operational planning

Waiting too long to upgrade may also reduce the availability of migration pathways, upgrade incentives, or transition support options that are more accessible today. 

Unplanned workflow disruption and reactive upgrade decisions 

One of the biggest hidden risks is waiting until an urgent issue forces a reactive upgrade decision. When laboratories delay planning until support has already ended - or until systems become difficult to maintain - they often face:

  • Unplanned workflow disruption
  • Greater downtime pressure
  • Reduced flexibility in upgrade scheduling
  • More urgent budget approvals
  • Increased strain on laboratory resources
  • Limited time for method transfer and user onboarding

By upgrading proactively, you can plan migration timelines around your operational priorities rather than around unexpected disruption.

This will allow your teams to:

  • Transition workflows gradually
  • Protect method continuity
  • Train users effectively
  • Minimize downtime risk
  • Maintain confidence across ongoing projects

Automated Workflows with the Sample Assistant 

Modern laboratories are under increasing pressure to deliver faster results, improve consistency, and reduce manual workload - all while managing growing sample volumes and increasingly complex analytical demands.

The combination of Zetasizer Advance and Sample Assistant has been designed to help laboratories modernize workflows through smarter automation, guided operation, and improved workflow efficiency.

By reducing manual intervention and streamlining routine analysis, teams can increase throughput, improve productivity, and spend more time focused on high-value scientific work.

With support for legacy Zetasizer Nano systems ending in 2027, now is the ideal time to future-proof your laboratory with a modern workflow platform designed for long-term operational efficiency. Upgrading to Zetasizer Advance with Sample Assistant provides laboratories with modern software compatibility, automated workflow capabilities, and long-term platform support - helping teams reduce downtime risk, improve workflow resilience, and prepare confidently for the future of laboratory automations.

Why upgrading now to Zetasizer Advance is the smart choice? 

With official support for Zetasizer Nano ending in 2027, you have a critical opportunity to plan ahead rather than react under pressure later. While existing systems may still be operational today, waiting too long to upgrade can introduce increasing risks around software compatibility, technical support availability, workflow disruption, and ageing hardware reliability.

Proactively upgrading now gives you greater control over timelines, budgets, training, and workflow continuity - helping avoid rushed decisions caused by unexpected downtime or unsupported systems.

Key advantages of upgrading to Zetasizer Advance include:

  • Long-term platform support beyond 2027
  • Faster, smarter results with Adaptive Correlation: Improve measurement speed, sensitivity and reproducibility so you can make critical decisions faster and with greater confidence
  • Higher-resolution particle sizing and particle concentration with MADLS: Deeper insights into complex and polydisperse samples, reducing uncertainty and improving formulation accuracy
  • Precise Zeta Potential using M3-PALS for stability prediction: Understand dispersion behaviour faster, helping reduce product failures and optimise shelf life
  • Automated workflows with the Sample Assistant: Increase throughput, reduce operator time and improve consistency across every measurement
  • Regulatory-ready compliance with OmniTrust: Support 21 CFR Part 11 and data integrity requirements with secure, traceable workflows built for regulated environments  

Most importantly, upgrading before obsolescence allows you to transition strategically rather than reactively. Instead of waiting for maintenance challenges, obsolete accessories, or unsupported software to disrupt critical workflows, teams can plan migration gradually, protect existing methods, and maintain confidence in daily operations.

For laboratories focused on productivity, operational resilience, and long-term analytical confidence, upgrading now is not simply replacing an instrument - you are investing in the future performance and stability of your laboratory itself.

 

Frequently asked questions

Do I really need to upgrade if I'm happy with my Zetasizer Nano?
There is no requirement to upgrade however as we've advised our technical and product support will end as we look to maintaining and further developing our Zetasizer Advance range. You will no longer be able to put their Zetasizer under service contracts, repair will be best efforts and spare part availability cannot be guaranteed.  We will make every effort to support your system, but what we can do will be more and more limited as spares etc. run out, causing possibly significant operational challenges for your lab.
What will happen if I don't upgrade?
You will find that there will be no further development on any systems or software upgrades and replacement part and accessories will eventually run out of supply.
I think I might need to upgrade but I'm not sure which Zetasizer would be the best fit. How do I go about deciding?

The best way is to fill out the form at the top of this page and one of our experts will be in touch. We can then discuss your workflows, assess your requirements and put together a package that best suits your needs.

Will my new results be comparable with historical Nano data?

Yes. The Zetasizer Advance range has been developed with continuity in mind, allowing users to compare historical Nano data with new measurements while benefiting from improved performance and enhanced data quality. Existing methods and long-term trend analysis can typically continue without disruption.

What is the biggest improvement compared with the Nano?

Many customers immediately notice improvements in sensitivity, repeatability and measurement speed. The introduction of our patented Adaptive Correlation technology helps distinguish genuine sample signals from noise, improving reliability and reducing the likelihood of poor-quality measurements. Users also benefit from enhanced software intelligence and clearer data interpretation.

Is the software different?

The ZS Xplorer software introduces a more modern and intuitive user experience while remaining familiar to existing Zetasizer users. Guided workflows, enhanced reporting, improved diagnostics and automated data quality guidance help simplify analysis and reduce training time. The software has been designed to improve productivity while increasing confidence in results.

How much training will my team need?

Most experienced Zetasizer Nano users adapt very quickly to the new system. The underlying measurement principles remain familiar, while the updated software interface and guided workflows help reduce the learning curve for both experienced and new users.

What is Adaptive Correlation?

Adaptive Correlation is a patented advanced technology that automatically optimises data collection and helps separate genuine particle signals from contamination or environmental noise. This improves measurement reproducibility, increases confidence in results and can reduce the need for extensive sample preparation.

Can the Advance range handle challenging samples better?

Yes. The combination of Non-Invasive Back Scatter technology, Adaptive Correlation and enhanced data analysis allows the Advance range to perform exceptionally well with difficult, weakly scattering, concentrated or complex samples. Many users see improved consistency and better quality data across a wider range of applications.

Is the Advance range suitable for regulated environments?

Yes. The updated software environment and enhanced data quality guidance help support laboratories operating within regulated industries, including pharmaceutical and biopharmaceutical sectors. The platform has been designed to support greater confidence, traceability and workflow consistency.